Goljan step 1 high yield notes download

Best example—Sarcoidosis a restrictive lung disease ; O 2 already have trouble getting through the membrane; with fibrosis it is worse. Another example—Pulmonary edema; O 2 cannot cross; therefore there is a diffusion defect.

These are the four things that cause hypoxemia resp acidosis, ventilation defects, perfusion defects, and diffusion defects. In the case of anemia, the classic misconception is a hypoxemia decrease in pO 2. There is NO hypoxemia in anemia, there is normal gas exchange normal respiration , therefore normal pO 2 and O 2 saturation, but there is a decrease in Hb. That is what anemia is: decrease in Hb. If you have 5 gm of Hb, there is not a whole lot of O 2 that gets to tissue, therefore get tissue hypoxia and the patient has exertional dyspnea with anemia, exercise intolerance.

Carbon monoxide CO : classic — heater in winter; in a closed space with a heater heater have many combustable materials; automobile exhaust and house fire.

When theres heat, cyanide gas is given off; therefore pts from house fires commonly have CO and cyanide poisoning. Clue was that O 2 did not correct the cyanosis. Most recent drug, Dapsone used to Rx leprosy is a sulfa and nitryl drug.

Therefore does two things: 1 produce methemoglobin and 2 have potential in producing hemolytic anemia in glucose 6 phosphate dehydrogenase deficiencies. Therefore, hemolysis in G6PD def is referring to oxidizing agents, causing an increase in peroxide, which destroys the RBC; the same drugs that produce hemolysis in G6PD def are sulfa and nitryl drugs.

These drugs also produce methemoglobin. Therefore, potential complication of that therapy is methemoglobinemia. Want a right shifted curve — want Hb with a decreased affinity for O 2 , so it can release O 2 to tissues. Most imp: cytochrome oxidase last enzyme before it transfers the electrons to O 2. Uncoupling — ability for inner mito membrane to synthesize ATP. Inner mito membrane is permeable to protons. Examples: dinitrylphenol chemical for preserving wood , alcohol, salicylates. Uncoupling agents causes protons to go right through the membrane; therefore you are draining all the protons, and very little ATP being made.

These are all the causes of tissue hypoxia ischemia, Hb related, cyto oxidase block, uncoupling agents. Absolute key things! Why do we have to use anaerobic glycolysis with tissue hypoxia? October 16, at pm UTC -4 Link to this comment. October 24, at am UTC -4 Link to this comment. November 1, at pm UTC -4 Link to this comment. January 11, at pm UTC -4 Link to this comment.

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Here's the most outstanding book without the need of audio , because there's a time saving transcribed book will do the work.

August 29, at am UTC -4 Link to this comment. February 11, at am UTC -4 Link to this comment. April 11, at am UTC -4 Link to this comment. April 18, at am UTC -4 Link to this comment. Thank you very much for the information, I am very grateful. I have been looking for the audio for more than a month.

April 22, at am UTC -4 Link to this comment. September 11, at pm UTC -4 Link to this comment. December 29, at pm UTC -4 Link to this comment. This is actually a common question. You certainly can not listen to some lectures and read one book and expect to pass.

If you have a great foundation of basic sciences, then this may be sufficient. Personally, I think it is also imperative to complete a question bank. How can you expect to have the mental stamina to complete 10 hours of medical testing if you have not subjected your mind to hundreds of hours of it in anticipation?

September 29, at am UTC -4 Link to this comment. January 28, at am UTC -4 Link to this comment. April 25, at am UTC -4 Link to this comment. July 28, at pm UTC -4 Link to this comment. April 26, at am UTC -4 Link to this comment. July 24, at am UTC -4 Link to this comment. This book is written by Dr. If you do not have these lectures, see my article and links about the subject because […]. Powered by WordPress and the Graphene Theme. Good luck. However, your data appear to be enough to get you many of the Any research you do is helpful, just find a good project and get involved.

Notify me of follow-up comments by email. Notify me of new posts by email. Been Medical Video Lectures Dr. Thursday, January 13, Sign in. Forgot your password? Get help. Privacy Policy. Password recovery. Note: If Link for Any Book is not working then kindly tell us in the comment box of that post, please try to avoid sending email.